Patrick Mahomes hasn’t thrown an interception in an NFL record six consecutive games and that streak is likely to continue today against a Bills team that’s going to be without star safety and lead ballhawk Taylor Rapp.

In Rapps’ place will be rookie Cole Bishop out of Utah, who will be lined up alongside FS Damar Hamlin in Buffalo’s secondary, which will almost certainly cause complications for the Bills two-high safety defense that crippled Mahomes and the Chiefs in their first meeting this season. 

Mahomes was 13 of 18 with an INT and just 5.2 yards per attempts versus two-high looks the first time these two teams met in November, and Mahomes has just a 5-to-6 TD-to-INT ratio with 6.4 yards per attempt when facing two-high looks overall this season. Luckily for Pat, that probably won’t be too much of an issue today.

With an inexperienced Bishop – who has had trouble grasping the Bills’ high-level defense this season – filling in for Rapp, I expect the Bills may have to resort to man coverage at some point in an effort to stop the Mahomes-Kelce connection in the middle of the field. That would just work further in Kansas City’s favor. The experience that dynamic Chiefs duo will be bringing against a shorthanded Bills defense will be the difference, and it could turn into an outright clinic if things go the way the trends are pointing. I expect very few mistakes out of Mahomes today, none of which will be an interception.

Mahomes hasn't thrown an interception since throwing two against the Bills in that initial meeting. One of those passes was intercepted by Rapp and that was the one that came in the two-high look, so really that just shows more of what Buffalo's defense will be missing when turning to Bishop on Sunday.